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Regulation of exogenous bFGF gene mediated by recombinant adeno-associated virus

Ke SONG, Nianjing RAO, Meiling CHEN, Yingguang CAO

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 158-163 doi: 10.1007/s11684-009-0042-5

Abstract: The regulatory effect of basic fibroblast growth factor (bFGF) mediated by recombinant adeno-associatedvirus (AAV) was investigated.co-transfected into BHK-21 cells, then the recombinant AAV genome was replicated and packaged with the helper virusparticle titer of rAAV2-tet-off-bFGF successfully constructed was 1.8×10 vector genomes/mL, and the virus

Keywords： tetracycline regulatory system     adeno-associated virus     basic fibroblast growth factor     gene regulation    

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Long-term correction of hemorrhagic diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composed of the human heavy chain and the rat light chain

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 584-595 doi: 10.1007/s11684-021-0844-7

Abstract: recombinant FVIII cDNA encoding a human/rat hybrid FVIII with an enhanced procoagulant potential for adeno-associatedvirus (AAV)-delivered gene therapy was developed.

Keywords： hemophilia A     adeno-associated virus (AAV)     human/rat hybrid factor VIII     gene therapy     dual chain strategy    

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Half-Life Extension Enhances Drug Efficacy in Adeno-Associated Virus Delivered Gene Therapy Article

Huifang Wu, Dan Hu, Quanxiao Li, Chunyu Wang, Xiaoyi Zhu, Wei Li, Binfan Chen, Ping Ji, Keke Huang, Ailing Huang, Jinghe Huang, Dimiter S. Dimitrov, Yanling Wu, Tianlei Ying

Engineering 2023, Volume 21, Issue 2,   Pages 203-213 doi: 10.1016/j.eng.2022.02.009

Abstract: the soluble monomeric immunoglobulin G 1 (IgG1) fragment crystallizable (sFc) or Fc region of IgG in adeno-associatedvirus (AAV)-delivered gene therapy.

Keywords： Gene therapy     Adeno-associated virus     Half-life     Fibroblast growth factor 21     Type 2 diabetes mellitus    

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Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral artery occlusion

Haiyan LU, Yongting WANG, Falei YUAN, Jianrong LIU, Lili ZENG, Guo-Yuan YANG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 86-93 doi: 10.1007/s11684-011-0118-x

Abstract: In the present study, we reported the delivery of NT-1 using an adeno-associated virus (AAV) vector (

Keywords： adeno-associated virus     angiogenesis     gene transfer     ischemia     middle cerebral artery occlusion     netrin-1    

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Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC: A case-control

Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 90-95 doi: 10.1007/s11684-010-0021-x

Abstract: promoter and evaluate their effects on the risk of primary hepatocellular carcinoma (HCC) with hepatitis B virus

Keywords： -2 gene     single nucleotide polymorphisms     susceptibility     primary hepatocellular carcinoma     hepatitis B virus    

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Removal of virus aerosols by the combination of filtration and UV-C irradiation

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 3, doi: 10.1007/s11783-023-1627-y

Abstract:

● The removal of virus aerosols by filtration and UV-C irradiation

Keywords： Filtration system     UV-C irradiation     Virus aerosol     Public health     COVID-19    

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Critical roles of chemokines and cytokines in antiviral innate immune responses during rabies virus infection

Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 260-267 doi: 10.15302/J-FASE-2016116

Abstract: pro-inflammatory chemokines and cytokines have a critical function in the innate immune responses against virusThe ability of a rabies virus (RABV) to induce the expression of chemokines and cytokines can lead to

Keywords： antiviral     blood brain barrier     chemokines and cytokines     innate immunity     rabies virus    

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Crk-associated substrate, vascular smooth muscle and hypertension

TANG Dale

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 323-331 doi: 10.1007/s11684-008-0062-6

Abstract: Crk-associated substrate (CAS), the first discovered member of the adapter protein CAS family, has been

Keywords： Contraction stimulation     phosphatase-proline     molecular structure     discovered     hypertension    

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Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 480-489 doi: 10.1007/s11684-017-0594-8

Abstract:

Superinfection is frequently detected among individuals infected by human immunodeficiency virus type

Keywords： human immunodeficiency virus type I     superinfection     incidence     immune response    

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Fanconi anemia gene-associated germline predisposition in aplastic anemia and hematologic malignancies

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 459-466 doi: 10.1007/s11684-021-0841-x

Abstract: Whether Fanconi anemia (FA) heterozygotes are predisposed to bone marrow failure and hematologic neoplasm is a crucial but unsettled issue in cancer prevention and family consulting. We retrospectively analyzed rare possibly significant variations (PSVs) in the five most obligated FA genes, BRCA2, FANCA, FANCC, FANCD2, and FANCG, in 788 patients with aplastic anemia (AA) and hematologic malignancy. Sixty-eight variants were identified in 66 patients (8.38%). FANCA was the most frequently mutated gene (n = 29), followed by BRCA2 (n = 20). Compared with that of the ExAC East Asian dataset, the overall frequency of rare PSVs was higher in our cohort (P = 0.016). BRCA2 PSVs showed higher frequency in acute lymphocytic leukemia (P = 0.038), and FANCA PSVs were significantly enriched in AA and AML subgroups (P = 0.020; P = 0.008). FA-PSV-positive MDS/AML patients had a higher tumor mutation burden, higher rate of cytogenetic abnormalities, less epigenetic regulation, and fewer spliceosome gene mutations than those of FA-PSV-negative MDS/AML patients (P = 0.024, P = 0.029, P = 0.024, and P = 0.013). The overall PSV enrichment in our cohort suggests that heterozygous mutations of FA genes contribute to hematopoietic failure and leukemogenesis.

Keywords： Fanconi anemia     aplastic anemia     hematologic malignancy     germline predisposition    

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New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 714-722 doi: 10.1007/s11684-021-0888-8

Abstract: A new definition of metabolic dysfunction-associated fatty liver disease (MAFLD) has recently been proposedParticipants without NAFLD but diagnosed according to MAFLD definition were associated with higher riskIn conclusion, MAFLD was associated with new-onset elevated baPWV and albuminuria independently of body

Keywords： metabolic dysfunction-associated fatty liver disease     non-alcoholic fatty liver disease     fibrosis score    

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Advances in newly developing therapy for chronic hepatitis C virus infection

Paul J. Pockros

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 166-174 doi: 10.1007/s11684-014-0334-2

Abstract:

Chronic hepatitis C virus (HCV) infection afflicts a reported 170 million people worldwide and is

Keywords： direct-acting antiviral (DAA)     nucleotide polymerase inhibitors     protease inhibitors    

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Universal influenza virus vaccines: what can we learn from the human immune response following exposure

Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 471-479 doi: 10.1007/s11684-017-0602-z

Abstract:

Several universal influenza virus vaccine candidates based on eliciting antibodies against the hemagglutininunderstanding of this phenomenon and the underlying mechanisms might help to develop future universal influenza virus

Keywords： universal influenza virus vaccine     hemagglutinin stalk     H7N9    

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Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection

Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 404-415 doi: 10.1007/s11684-021-0834-9

Abstract: Zika virus (ZIKV) is an emerging pathogen associated with neurological complications, such as Guillain–Barré

Keywords： Zika virus     clinical drugs     ZIKV inhibitors     antivirals     repurposing    

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Dynamics of foot-and-mouth disease virus replication in cells at different phases of the cell-division

Claudia DOEL,Zhidong ZHANG,Lise MAZELET,Ryan WATERS,John BASHIRUDDIN

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 3,   Pages 250-257 doi: 10.15302/J-FASE-2014031

Abstract: Foot-and-mouth-disease virus (FMDV) replicates in epithelial cells.

Keywords： foot-and-mouth disease virus     cell cycle     replication    

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Title Author Date Type Operation

Regulation of exogenous bFGF gene mediated by recombinant adeno-associated virus

Ke SONG, Nianjing RAO, Meiling CHEN, Yingguang CAO

Journal Article

Long-term correction of hemorrhagic diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composed of the human heavy chain and the rat light chain

Journal Article

Half-Life Extension Enhances Drug Efficacy in Adeno-Associated Virus Delivered Gene Therapy

Huifang Wu, Dan Hu, Quanxiao Li, Chunyu Wang, Xiaoyi Zhu, Wei Li, Binfan Chen, Ping Ji, Keke Huang, Ailing Huang, Jinghe Huang, Dimiter S. Dimitrov, Yanling Wu, Tianlei Ying

Journal Article

Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral artery occlusion

Haiyan LU, Yongting WANG, Falei YUAN, Jianrong LIU, Lili ZENG, Guo-Yuan YANG

Journal Article

Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC: A case-control

Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,

Journal Article

Removal of virus aerosols by the combination of filtration and UV-C irradiation

Journal Article

Critical roles of chemokines and cytokines in antiviral innate immune responses during rabies virus infection

Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU

Journal Article

Crk-associated substrate, vascular smooth muscle and hypertension

TANG Dale

Journal Article

Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Journal Article

Fanconi anemia gene-associated germline predisposition in aplastic anemia and hematologic malignancies

Journal Article

New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse

Journal Article

Advances in newly developing therapy for chronic hepatitis C virus infection

Paul J. Pockros

Journal Article

Universal influenza virus vaccines: what can we learn from the human immune response following exposure

Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer

Journal Article

Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection

Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang

Journal Article

Dynamics of foot-and-mouth disease virus replication in cells at different phases of the cell-division

Claudia DOEL,Zhidong ZHANG,Lise MAZELET,Ryan WATERS,John BASHIRUDDIN

Journal Article